Take Amitriptyline exactly as directed by your doctor. Do not take more or less than instructed by your doctor. – You may take Amitriptyline with or without food. – Amitriptyline must be taken regularly for it to work well. You may see the benefits of Amitriptyline only after 2-4 weeks. Do not be discouraged if you do not feel better soon after taking the medicine. Do not stop taking Amitriptyline unless instructed by your doctor. You may feel unwell if Amitriptyline is stopped suddenly.